Phenotypes Associated with This Genotype

Genotype
MGI:3525258

• Allelic Composition: Lgals3bp^tm1Megt/Lgals3bp^tm1Megt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/Ka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased circulating interferon-gamma level ( J:94936 )

• 5- to 10-fold higher interferon-gamma levels in serum in response to LPS

increased circulating interleukin-12 level ( J:94936 )

• elevated serum IL-12 p70 levels in response to LPS

increased tumor necrosis factor secretion ( J:94936 )

• peritoneal lavages, but not serum, of homozygotes showed a significant increase in TNF-alpha levels after LPS challenge

• peritoneal excudate cells from both homozygotes and wild-types secreted more TNF-alpha in response to LPS when cultured in serum from mutants than in serum from wild-type

increased susceptibility to endotoxin shock ( J:94936 )

• increased sensitivity to LPS resulted in a higher percentage of homozygotes dying compared to wild-type

homeostasis/metabolism

increased circulating interferon-gamma level ( J:94936 )

• 5- to 10-fold higher interferon-gamma levels in serum in response to LPS

increased circulating interleukin-12 level ( J:94936 )

• elevated serum IL-12 p70 levels in response to LPS