Phenotypes Associated with This Genotype

Genotype
MGI:3525205

• Allelic Composition: Stk17b^tm1Hed/Stk17b^tm1Hed
• Genetic Background: B6.129X1-Stk17b^tm1Hed

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell proliferation ( J:94685 )

• mutant T cells are hypersensitive to antigen stimulated proliferation, however no defect in induced thymocyte apoptosis is seen

• this increase is less pronounced than in B6.129P2-Cblb^tm1Hua homozygotes

decreased double-positive T cell number ( J:94685 )

increased CD4-positive, alpha-beta T cell number ( J:94685 )

• a slight yet significant increase in the percentage of CD4 single positive thymocytes is seen

increased memory T cell number ( J:94685 )

• an increase in the number of T cells with characteristics of memory T cells is seen

immune system

increased T cell proliferation ( J:94685 )

• mutant T cells are hypersensitive to antigen stimulated proliferation, however no defect in induced thymocyte apoptosis is seen

• this increase is less pronounced than in B6.129P2-Cblb^tm1Hua homozygotes

decreased double-positive T cell number ( J:94685 )

increased CD4-positive, alpha-beta T cell number ( J:94685 )

• a slight yet significant increase in the percentage of CD4 single positive thymocytes is seen

increased memory T cell number ( J:94685 )

• an increase in the number of T cells with characteristics of memory T cells is seen

abnormal cytokine secretion ( J:94685 )

increased interferon-gamma secretion ( J:94685 )

• after infection with the lymphocytic choriomeningitis virus increased levels of IFN-gamma are seen before the peak of infection and during the contraction phase

increased interleukin-2 secretion ( J:94685 )

• more IL-2 is produced by nave T cells in response to anti-CD3 stimulation

• this increase is less pronounced than in B6.129P2-Cblb^tm1Hua homozygotes

• under nonskewing conditions mutant T helper cells produce more IL2 and IL4

increased tumor necrosis factor secretion ( J:94685 )

• under nonskewing conditions mutant T helper cells produce more TNF

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:94685 )

• both the incidence and severity of experimental autoimmune encephalomyelitis are decreased in mutants

cellular

increased T cell proliferation ( J:94685 )

• mutant T cells are hypersensitive to antigen stimulated proliferation, however no defect in induced thymocyte apoptosis is seen

• this increase is less pronounced than in B6.129P2-Cblb^tm1Hua homozygotes