Phenotypes Associated with This Genotype

Genotype
MGI:3525169

• Allelic Composition: Notch1^tm2Rko/Notch1^tm2Rko; Tg(Msx2-cre)5Rem/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

small sebaceous gland ( J:94517 )

• severely reduced sebaceous glands in embryo-deleted skin

integument

small sebaceous gland ( J:94517 )

• severely reduced sebaceous glands in embryo-deleted skin

abnormal hair growth ( J:94517 )

• mosaic pattern of hair growth (regions of finer, shorter, and wavy hairs that showed twisted, knotted morphology resulting from Cre expression at E9.5 and regions of normal hairs resulting from Cre expression at P1) that was maintained throughout life

short hair ( J:94517 )

waved hair ( J:94517 )

• regions of wavy hair that have a twisted, knotted morphology

abnormal hair shaft morphology ( J:94517 )

• bulbous perturbations in the shaft

abnormal hair follicle morphology ( J:94517 )

• medulla layer of embryo-deleted follicles was disorganized, with two smaller cells, instead of one, packed inside the medulla with fewer, disorganized trichohyalin granules

disorganized inner root sheath cells ( J:94517 )

• the inner root sheath Henle's layer of embryo-deleted follicles is improperly organized with up to four cell tips in the mutant hair instead of two

• however, the cortex is normal