endocrine/exocrine glands
• severely reduced sebaceous glands in embryo-deleted skin
|
integument
• severely reduced sebaceous glands in embryo-deleted skin
|
• mosaic pattern of hair growth (regions of finer, shorter, and wavy hairs that showed twisted, knotted morphology resulting from Cre expression at E9.5 and regions of normal hairs resulting from Cre expression at P1) that was maintained throughout life
|
short hair
(
J:94517
)
waved hair
(
J:94517
)
• regions of wavy hair that have a twisted, knotted morphology
|
• bulbous perturbations in the shaft
|
• medulla layer of embryo-deleted follicles was disorganized, with two smaller cells, instead of one, packed inside the medulla with fewer, disorganized trichohyalin granules
|
• the inner root sheath Henle's layer of embryo-deleted follicles is improperly organized with up to four cell tips in the mutant hair instead of two
• however, the cortex is normal
|