About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3525159
Allelic
Composition
Nfatc2tm1Glm/Nfatc2tm1Glm
Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2tm1Glm mutation (0 available); any Nfatc2 mutation (53 available)
Nfatc3tm1Glm mutation (1 available); any Nfatc3 mutation (70 available)
Nfatc4tm1Grc mutation (1 available); any Nfatc4 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• smaller than stage matched controls
• stages were not delayed

growth/size/body
• smaller than stage matched controls
• stages were not delayed

nervous system
• defects in sensory axon projections found in 100% of triple mutants
• spinal sensory neurons failed to project longitudinally
• commissural axon growth is disrupted
• trigeminal axons stunted at E10.5
• dorsal funiculus absent or fragmented

behavior/neurological
• mutants display decreased grip strength compared to controls
• mice show increased locomotor activity compared to BALB/c controls
• mutants show increased social interaction

muscle

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685
J:109139


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory