Phenotypes Associated with This Genotype

Genotype
MGI:3525157

• Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm; Nfatc3^tm1Glm/Nfatc3^tm1Glm
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:51339 )

• modest

enlarged spleen ( J:51339 )

• massive splenomegaly by 7 weeks of age

• normal architecture is disrupted

• increased numbers of mast cells and eosinophiles

• spontaneous proliferation of splenocytes

hematopoietic system

enlarged spleen ( J:51339 )

• massive splenomegaly by 7 weeks of age

• normal architecture is disrupted

• increased numbers of mast cells and eosinophiles

• spontaneous proliferation of splenocytes

abnormal lymphocyte cell number ( J:51339 )

increased B cell number ( J:51339 )

• increased percentage of B220+ cells in lymph nodes

decreased T cell number ( J:51339 )

• decreased numbers of CD3+ T cells in lymph nodes

• decreased ratio of double positive T cells in lymph nodes

increased T cell number ( J:51339 )

• increased percentage of memory activated T cells in periphery

• increased proportion of double positive T cells in spleen

immune system

enlarged spleen ( J:51339 )

• massive splenomegaly by 7 weeks of age

• normal architecture is disrupted

• increased numbers of mast cells and eosinophiles

• spontaneous proliferation of splenocytes

abnormal lymphocyte cell number ( J:51339 )

increased B cell number ( J:51339 )

• increased percentage of B220+ cells in lymph nodes

decreased T cell number ( J:51339 )

• decreased numbers of CD3+ T cells in lymph nodes

• decreased ratio of double positive T cells in lymph nodes

increased T cell number ( J:51339 )

• increased percentage of memory activated T cells in periphery

• increased proportion of double positive T cells in spleen

abnormal lymph node morphology ( J:51339 )

• lymph node cells increased 2-3 fold

• increased numbers of eosinophiles

increased inflammatory response ( J:51339 )

blepharitis ( J:51339 )

• bilateral blepharitis by for weeks of age

• eyelids with edema and marked inflammatory infiltrates

interstitial pneumonia ( J:51339 )

• inflammatory infiltrate containing lymphocytes, macrophage, neutrophiles, and mast cells

respiratory system

interstitial pneumonia ( J:51339 )

• inflammatory infiltrate containing lymphocytes, macrophage, neutrophiles, and mast cells

vision/eye

blepharitis ( J:51339 )

• bilateral blepharitis by for weeks of age

• eyelids with edema and marked inflammatory infiltrates