Phenotypes Associated with This Genotype

Genotype
MGI:3525070

• Allelic Composition: Cd209b^tm1Anjm/Cd209b^tm1Anjm
• Genetic Background: B6.129P2-Cd209b^tm1Anjm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased susceptibility to induced colitis ( J:159646 )

• mice exhibit reduced susceptibility to dextran sodium sulfate (DSS)-induced colitis, showing less severe colitis, less shortening of the colon, less inflammation and colon damage, and decreased proinflammatory cytokine levels

immune system

decreased susceptibility to induced colitis ( J:159646 )

• mice exhibit reduced susceptibility to dextran sodium sulfate (DSS)-induced colitis, showing less severe colitis, less shortening of the colon, less inflammation and colon damage, and decreased proinflammatory cytokine levels

decreased interleukin-1 beta secretion ( J:159646 )

• peritoneal macrophages show reduced LPS-induced lL-1beta production

decreased interleukin-18 secretion ( J:159646 )

• peritoneal macrophages show reduced LPS-induced IL-18 production

decreased susceptibility to endotoxin shock ( J:159646 )

• mice show reduced susceptibility to LPS-induced shock, showing higher survival, reduced clinical signs of shock and reduced proinflammatory levels

increased susceptibility to bacterial infection induced morbidity/mortality ( J:94698 )

• only 40% of homozygous mutants survive 48 hours after intraperitoneal infection with 10³ S. pneumoniae compared to 100% of wild-type and 0% survive after infection with 10⁴ S. pneumoniae compared to 90% in wild-type

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:94698 )

• only 40% of homozygous mutants survive 48 hours after intraperitoneal infection with 10³ S. pneumoniae compared to 100% of wild-type and 0% survive after infection with 10⁴ S. pneumoniae compared to 90% in wild-type