Analysis Tools
cellular
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• fewer than half as many macrophages phagocytosed S. pneumoniae at 37C compared with controls, with the reduction in phagocytosis being proportional to the reduction in surface binding
• marginal zone macrophages of the spleen failed to phagocytose the polysaccharide dextran
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mortality/aging
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• more rapid mortality after S. pneumoniae infection, with only 20% of homozygotes surviving at 48 hours compared to 90% of wild-type
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immune system
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• peritoneal macrophages were impaired (3-fold reduction) in ability to bind S. pneumoniae at 4C after infection
• marginal zone macrophages in the spleen were impaired in trapping S.pneumoniae in the marginal zone and clearing the bacteria from the circulation
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• fewer than half as many macrophages phagocytosed S. pneumoniae at 37C compared with controls, with the reduction in phagocytosis being proportional to the reduction in surface binding
• marginal zone macrophages of the spleen failed to phagocytose the polysaccharide dextran
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• less than 18% of homozygotes survived infection with S. pneumoniae compared with more than 60% of wild-type and exhibited persistent septicemia after infection compared with controls
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• more rapid mortality after S. pneumoniae infection, with only 20% of homozygotes surviving at 48 hours compared to 90% of wild-type
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hematopoietic system
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• peritoneal macrophages were impaired (3-fold reduction) in ability to bind S. pneumoniae at 4C after infection
• marginal zone macrophages in the spleen were impaired in trapping S.pneumoniae in the marginal zone and clearing the bacteria from the circulation
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• fewer than half as many macrophages phagocytosed S. pneumoniae at 37C compared with controls, with the reduction in phagocytosis being proportional to the reduction in surface binding
• marginal zone macrophages of the spleen failed to phagocytose the polysaccharide dextran
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