Phenotypes Associated with This Genotype

Genotype
MGI:3522668

• Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc; Tg(Alb1-cre)1Khk/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:94883 )

• 40% were dead by E14.5 and 70% were dead by E15.5; some animals survived until birth; heterogeneity of cre recombinase activity is suggested to result in these variable phenotypes

cellular

abnormal cell cycle ( J:94883 )

• decrease in BrdU incorporation without increase in apoptosis suggesting a block in mitosis

liver/biliary system

abnormal liver sinusoid morphology ( J:94883 )

• disruption in the organization of liver sinusoids; variable penetrance

abnormal intrahepatic bile duct morphology ( J:94883 )

• abnormal development of the intrahepatic bile ducts

abnormal hepatoblast morphology ( J:94883 )

• presence of abnormal hepatoblast cells with enlarged polyploid nuclei

• decrease in BrdU incorporation without increase in apoptosis suggesting a block in mitosis

decreased hepatoblast number ( J:94883 )

• reduced numbers of hepatoblasts; 50% reduction in the number of hepatoblasts compared to controls, but no decrease in overall size of liver suggesting a hypertrophy of remaining hepatoblasts

abnormal hepatic cord morphology ( J:94883 )

• disruption in the organization of hepatic cords; variable penetrance

cardiovascular system

abnormal liver sinusoid morphology ( J:94883 )

• disruption in the organization of liver sinusoids; variable penetrance

abnormal hepatic vein morphology ( J:94883 )

• reduction in the number of large hepatic veins; variable penetrance

endocrine/exocrine glands

abnormal intrahepatic bile duct morphology ( J:94883 )

• abnormal development of the intrahepatic bile ducts