Phenotypes Associated with This Genotype

Genotype
MGI:3522658

• Allelic Composition: Srf^tm1Rmn/Srf^tm1Rmn; Tg(Tagln-cre)1Jomm/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:94725 )

• no viable embryos are found after E11.5

cardiovascular system

vascular smooth muscle hypotrophy ( J:94725 )

• a 35% decrease in smooth muscle cells at the dorsal aspect of the aorta is found

abnormal myocardial fiber morphology ( J:94725 )

• the sarcomeres and Z disks are disorganized and the myofilaments are disarrayed

muscle

vascular smooth muscle hypotrophy ( J:94725 )

• a 35% decrease in smooth muscle cells at the dorsal aspect of the aorta is found

abnormal myocardial fiber morphology ( J:94725 )

• the sarcomeres and Z disks are disorganized and the myofilaments are disarrayed