Phenotypes Associated with This Genotype

Genotype
MGI:3522633

• Allelic Composition: Zbtb32^tm1Iho/Zbtb32^tm1Iho
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:94944 )

• hyperproliferation of Th cells is seen in response to suboptimal stimulation with anti-CD3

• however susceptibility to experimental autoimmune encephalomyelitis (EAE) is similar to wild-type

abnormal cytokine secretion ( J:94944 )

• stimulated Th cells produce more IL-2 and slightly more IL-4 and dendritic cells produce 50% more IL-12p40

hematopoietic system

increased T cell proliferation ( J:94944 )

• hyperproliferation of Th cells is seen in response to suboptimal stimulation with anti-CD3

• however susceptibility to experimental autoimmune encephalomyelitis (EAE) is similar to wild-type

cellular

increased T cell proliferation ( J:94944 )

• hyperproliferation of Th cells is seen in response to suboptimal stimulation with anti-CD3

• however susceptibility to experimental autoimmune encephalomyelitis (EAE) is similar to wild-type