Mouse Genome Informatics
hm
    Lama2tm1Eeng/Lama2tm1Eeng
involves: 129S1/Sv * Black Swiss * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most die within 2-4 weeks after birth though a few survive up to 3-4 months
• most die within 2-4 weeks after birth though a few survive up to 3-4 months

behavior/neurological
• homozygotes were passive
• from 2-3 weeks of age, flexed hind legs to the trunk when lifted by the tail
• hindlimbs become increasingly paralyzed with age

growth/size
• 1 and 3 month old mutants are smaller and thinner than wild-type

muscle
• showed extensive muscle degeneration, muscle fiber necrosis and pronounced fibrosis

Mouse Models of Human Disease
OMIM IDRef(s)
Muscular Dystrophy, Congenital Merosin-Deficient, 1A; MDC1A 607855 J:49435