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Phenotypes Associated with This Genotype
Genotype
MGI:3522485
Allelic
Composition
Lama2tm1Eeng/Lama2tm1Eeng
Genetic
Background
involves: 129S1/Sv * Black Swiss * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2tm1Eeng mutation (1 available); any Lama2 mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die within 2-4 weeks after birth though a few survive up to 3-4 months
• most die within 2-4 weeks after birth though a few survive up to 3-4 months

behavior/neurological
• homozygotes were passive
• from 2-3 weeks of age, flexed hind legs to the trunk when lifted by the tail
• hindlimbs become increasingly paralyzed with age

growth/size/body
• 1 and 3 month old mutants are smaller and thinner than wild-type

muscle
• showed extensive muscle degeneration, muscle fiber necrosis and pronounced fibrosis

Mouse Models of Human Disease
OMIM ID Ref(s)
Muscular Dystrophy, Congenital Merosin-Deficient, 1A; MDC1A 607855 J:49435


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory