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Phenotypes Associated with This Genotype
Genotype
MGI:3522485
Allelic
Composition
Lama2tm1Eeng/Lama2tm1Eeng
Genetic
Background
involves: 129S1/Sv * Black Swiss * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2tm1Eeng mutation (2 available); any Lama2 mutation (177 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die within 2-4 weeks after birth though a few survive up to 3-4 months
• most die within 2-4 weeks after birth though a few survive up to 3-4 months

behavior/neurological
• homozygotes were passive
• from 2-3 weeks of age, flexed hind legs to the trunk when lifted by the tail
• hindlimbs become increasingly paralyzed with age

growth/size/body
• 1 and 3 month old mutants are smaller and thinner than wild-type

muscle
• showed extensive muscle degeneration, muscle fiber necrosis and pronounced fibrosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital merosin-deficient muscular dystrophy 1A DOID:0110636 OMIM:607855
J:49435


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory