Phenotypes for Cry2 Per2 MGI:3522463 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cry2^tm1Jhjh/Cry2^tm1Jhjh Per2^tm1Brd/Per2^tm1Brd
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry2^tm1Jhjh mutation (0 available); any Cry2 mutation (43 available)
Per2^tm1Brd mutation (1 available); any Per2 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased osteoblast cell number ( J:163112 )

decreased bone ossification ( J:163112 )

• mice exhibit decreased bone formation rate compared with wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:79492 )

• double homozygotes entrain to the LD cycle, displaying locomotor activity patterns similar to those of wild-type

• unexpectedly, double homozygotes are able to maintain a circadian rhythm in DD (rescue of circadian rhythmicity)

• profiles of cycling clock genes in the SCN indicate normal circadian behavior and core oscillator performance

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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