Phenotypes Associated with This Genotype

Genotype
MGI:3522337

• Allelic Composition: Ephb6^tm1Jwu/Ephb6^tm1Jwu
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:94701 )

• 72 hours after activation, proliferation of stimulated mutant thymocytes and spleen T-cells in vitro was decreased compared to wild-type cells

decreased susceptibility to type IV hypersensitivity reaction ( J:94701 )

• development of delayed-type skin hypersensitivity was compromised, however humoral immune responses were normal

abnormal cytokine secretion ( J:94701 )

• reduced IFN-gamma, IL-2, and IL-4 secretion at 48 hours after activation of mutant spleen T cells in culture

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:94701 )

• induction of experimental autoimmune encephalitis was significantly reduced compared to wild-type

hematopoietic system

decreased T cell proliferation ( J:94701 )

• 72 hours after activation, proliferation of stimulated mutant thymocytes and spleen T-cells in vitro was decreased compared to wild-type cells

cellular

decreased T cell proliferation ( J:94701 )

• 72 hours after activation, proliferation of stimulated mutant thymocytes and spleen T-cells in vitro was decreased compared to wild-type cells