Phenotypes Associated with This Genotype

Genotype
MGI:3521979

• Allelic Composition: Met^tm1Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:94722 )

• 58.8% tumor incidence compared to 44.4% in controls, with some developing multiple cancers

increased lymphoma incidence ( J:94722 )

• increased incidence of lymphomas, especially histiocytic sarcomas

increased histiocytic sarcoma incidence ( J:94722 )

increased carcinoma incidence ( J:94722 )

• increased incidence of various carcinomas including transitional cell and squamous cell carcinoma

increased squamous cell carcinoma incidence ( J:94722 )

cellular

chromosome breakage ( J:94722 )

• trisomy and tetrasomy of chromosome 6 and duplication of the mutant Met allele were observed in tumors

immune system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

renal/urinary system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

hydronephrosis ( J:94722 )

• infrequent to moderate incidence of hydronephrosis