Phenotypes Associated with This Genotype

Genotype
MGI:3521928

• Allelic Composition: Top2b^tm2Jcw/Top2b^tm2.1Jcw; Foxg1^tm1(cre)Skm/Foxg1⁺
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:94879 )

• died of respiratory failure within 30 min after birth, however decreased body size was not observed as in homozygous Top2b mutant mice

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:94879 )

• lack the vigor of wild-type newborns, however show some body movements upon tactile stimulation

respiratory system

atelectasis ( J:94879 )

respiratory failure ( J:94879 )

• collapsed lung alveoli in dead pups suggests respiratory failure

nervous system

abnormal hippocampus morphology ( J:94879 )

abnormal hippocampus granule cell layer ( J:94879 )

• ill-defined granule cell layer in the hippocampus

abnormal hippocampus pyramidal cell layer ( J:94879 )

• ill-defined pyramidal cell layer in the hippocampus

abnormal cerebral cortex morphology ( J:94879 )

• thinner cortex

small olfactory bulb ( J:94879 )

• less developed olfactory bulb