Phenotypes Associated with This Genotype

Genotype
MGI:3521908

• Allelic Composition: Adcyap1^tm1Clw/Adcyap1^tm1Clw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:94880 )

• 50-80% of the expected number of homozygotes are found at the time of genotyping

behavior/neurological

increased locomotor activity ( J:94880 )

• increased wheel-running activity is seen with a 12:12 light:dark cycle

shortened circadian behavior period ( J:94880 )

• the free running period is about 20 minutes shorter, however no difference in synchronization to a light dark cycle or responding to shifts in the light dark cycle are seen

abnormal circadian behavior phase ( J:94880 )

• a significant shortening of the phase angle of entrainment is seen

• in constant dark, a significant reduction in the phase advance induced by a single discrete light treatment is seen when either bright or dim light is used