Phenotypes Associated with This Genotype

Genotype
MGI:3521905

• Allelic Composition: Ahr^tm3Bra/Ahr^tm3Bra
• Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

patent ductus venosus ( J:94465 )

• a patent ductus venosus (shunting blood around the liver) was seen in 22/25 mutants

• exposure to a non-teratogenic concentration of dioxin on E12.5, E14.5, E16.5 or E18.5 resulted in closure of the ductus venosus in all mutants

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:94465 )

• a 7-fold lower increase in ethoxyresorufin-O-deethylase activity is seen compared to Ahr^d homozygotes

cellular

patent ductus venosus ( J:94465 )

• a patent ductus venosus (shunting blood around the liver) was seen in 22/25 mutants

• exposure to a non-teratogenic concentration of dioxin on E12.5, E14.5, E16.5 or E18.5 resulted in closure of the ductus venosus in all mutants