Phenotypes for Sdc1 Tg(Wnt1)1Hev MGI:3521902 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sdc1^tm1Cma/Sdc1⁺ Tg(Wnt1)1Hev/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1^tm1Cma mutation (0 available); any Sdc1 mutation (21 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:63122 )

• 30% of hemizygous females expressing the transgene in a Sdc1^tm1Cma heterozygous null background develop mammary tumors (median time: ~25 weeks) versus 34% of hemizygous females in a Sdc1 wild-type background (median time: ~21 weeks)

• these Wnt1-induced tumors are predominantly alveolar adenocarcinomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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