Phenotypes Associated with This Genotype

Genotype
MGI:3521901

• Allelic Composition: Sdc1^tm1Cma/Sdc1^tm1Cma; Tg(Wnt1)1Hev/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor incidence ( J:63122 )

• only 3% of hemizygous females expressing the transgene in a Sdc1^tm1Cma null background develop mammary tumors (median time: ~36 weeks) versus 34% of hemizygous females in a Sdc1 wild-type background (median time: ~21 weeks)

• these Wnt1-induced tumors are predominantly alveolar adenocarcinomas

endocrine/exocrine glands

mammary gland hyperplasia ( J:63122 )

♀ • hemizygous females expressing the transgene in a Sdc1^tm1Cma null background exhibit a ~70% inhibition of Wnt1-induced mammary gland hyperplasia relative to hemizygous females of a Sdc1 wild-type background

integument

mammary gland hyperplasia ( J:63122 )

♀ • hemizygous females expressing the transgene in a Sdc1^tm1Cma null background exhibit a ~70% inhibition of Wnt1-induced mammary gland hyperplasia relative to hemizygous females of a Sdc1 wild-type background