Phenotypes Associated with This Genotype

Genotype
MGI:3521754

• Allelic Composition: Ccr9^tm1Ccb/Ccr9^tm1Ccb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased thymocyte number ( J:94596 )

• at E12.5 and E13.5 a 2- and 2.9-fold, respectively, reduction in thymocytes is seen, however at E11.5 no difference in thymocyte numbers is detected

abnormal T cell differentiation ( J:94596 )

• proliferating thymocytes, including DN2/3 cells, are found throughout the cortex rather than being confined to the subcapsular zone, however the number of these cells is not different from wild-type mice

immune system

decreased thymocyte number ( J:94596 )

• at E12.5 and E13.5 a 2- and 2.9-fold, respectively, reduction in thymocytes is seen, however at E11.5 no difference in thymocyte numbers is detected

abnormal T cell differentiation ( J:94596 )

• proliferating thymocytes, including DN2/3 cells, are found throughout the cortex rather than being confined to the subcapsular zone, however the number of these cells is not different from wild-type mice

endocrine/exocrine glands

decreased thymocyte number ( J:94596 )

• at E12.5 and E13.5 a 2- and 2.9-fold, respectively, reduction in thymocytes is seen, however at E11.5 no difference in thymocyte numbers is detected