Phenotypes Associated with This Genotype

Genotype
MGI:3521739

• Allelic Composition: Tg(Ttr-Foxo1)307Dac/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:94423 )

• higher plasma cholesterol levels in heparinized transgenic mice (136 mg/dl) compared to wild-type (109 mg/dl)

increased circulating HDL cholesterol level ( J:94423 )

increased circulating triglyceride level ( J:94423 )

• approximately twofold increase in plasma triglyceride levels and elevated plasma VLDL-triglyceride levels

• triglyceride levels were elevated in response to a fat tolerance test and remained high even after 4 hours compared to wild-type