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Phenotypes Associated with This Genotype
Genotype
MGI:3514287
Allelic
Composition		 Spout1tm1Mxu/Spout1+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spout1tm1Mxu mutation (0 available); any Spout1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased sensitivity to induced cell death ( J:88144 )
• reduced apoptosis and DNA fragmentation is seen in splenocytes, thymocytes, and MEFs after treatment with apoptotic stimuli
abnormal male germ cell apoptosis ( J:88144 )
• reduced amount of spontaneous apoptosis during spermatogenesis relative to wild-type

reproductive system
abnormal male germ cell apoptosis ( J:88144 )
• reduced amount of spontaneous apoptosis during spermatogenesis relative to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory