Analysis Tools
mortality/aging
skeleton
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• supernumerary teeth lingual to the molars
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craniofacial
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• supernumerary teeth lingual to the molars
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• at E13.5, palatal mesenchyme cell proliferation is reduced by 37% in the medial halves of the downward growing palatal shelves but not in the lateral halves, resulting in retarded, mediolaterally symmetric palatal shelves at E14.5
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• palatal shelves are elevated but fail to contact each other at the midline at E15.5
• however, palatal outgrowth and initial downward palatal growth are normal
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• homozygous mutant palatal shelves are separated from each other at E15.5, resulting in bilateral cleft of the secondary palate at birth
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• palatal shelves appear retarded at E14.5 and are are still vertically oriented at E15.0
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• bilateral cleft palate
(J:149458)
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hearing/vestibular/ear
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• the tympanic rings are thicker in mutants compared to wild-type mice
(J:94755)
• thickened
(J:149458)
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vision/eye
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• delay in eyelid outgrowth and a reduction in cell proliferation in the upper and lower eyelid epithelium and mesenchymel at E13.5
• at E15.5 eyelids appear round and lack the periderm leading edges seen in wild-type controls
• by E18.5 a rudimentary periderm leading edge is present
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• eyelids are not fused at E18.5
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digestive/alimentary system
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• at E13.5, palatal mesenchyme cell proliferation is reduced by 37% in the medial halves of the downward growing palatal shelves but not in the lateral halves, resulting in retarded, mediolaterally symmetric palatal shelves at E14.5
|
|
• palatal shelves are elevated but fail to contact each other at the midline at E15.5
• however, palatal outgrowth and initial downward palatal growth are normal
|
|
• homozygous mutant palatal shelves are separated from each other at E15.5, resulting in bilateral cleft of the secondary palate at birth
|
|
• palatal shelves appear retarded at E14.5 and are are still vertically oriented at E15.0
|
|
• bilateral cleft palate
(J:149458)
|
growth/size/body
|
• supernumerary teeth lingual to the molars
|
|
• at E13.5, palatal mesenchyme cell proliferation is reduced by 37% in the medial halves of the downward growing palatal shelves but not in the lateral halves, resulting in retarded, mediolaterally symmetric palatal shelves at E14.5
|
|
• palatal shelves are elevated but fail to contact each other at the midline at E15.5
• however, palatal outgrowth and initial downward palatal growth are normal
|
|
• homozygous mutant palatal shelves are separated from each other at E15.5, resulting in bilateral cleft of the secondary palate at birth
|
|
• palatal shelves appear retarded at E14.5 and are are still vertically oriented at E15.0
|
|
• bilateral cleft palate
(J:149458)
|
