Phenotypes for Hand1 Rr133 Tg(Nkx2-5-cre)9Eno MGI:3514076 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hand1^tm1Eno/Hand1^tm2Eno Rr133^tm1Eno/Rr133⁺ Tg(Nkx2-5-cre)9Eno/0
Genetic Background	either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1^tm1Eno mutation (1 available); any Hand1 mutation (14 available)
Hand1^tm2Eno mutation (0 available); any Hand1 mutation (14 available)
Rr133^tm1Eno mutation (0 available); any Rr133 mutation (0 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:94514 )

• no mutant embryos are found after E10.5

cardiovascular system

abnormal myocardial trabeculae morphology ( J:94514 )

• at E10.5 the myocardium is poorly trabeculated

thin myocardium ( J:94514 )

• at E10.5 the myocardium is thin

embryo

embryonic growth retardation ( J:94514 )

• at E10.5 mutant embryos appear slightly delayed compared to compound heterozygotes lacking only Hand1

muscle