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Phenotypes Associated with This Genotype
Genotype
MGI:3514074
Allelic
Composition		 Hand1tm1Eno/Hand1tm2Eno
Tg(Nkx2-5-cre)9Eno/0
Genetic
Background		 either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation (1 available); any Hand1 mutation (14 available)
Hand1tm2Eno mutation (0 available); any Hand1 mutation (14 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:94514 )
• most mutants die within 2-4 days of birth

cardiovascular system
abnormal heart morphology ( J:94514 )
• heart defects similar to those seen in compound heterozygotes hemizygous for Tg(Myhca-cre)2182Mds are found

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory