Phenotypes Associated with This Genotype

Genotype
MGI:3513828

• Allelic Composition: Grin2c^{tm1(Grin2b)Ulme}/Grin2c^{tm1(Grin2b)Ulme}
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:94369 )

• on a fixed speed rotarod test, motor deficits gradually increased with age, with no difference in time spend on the rod at 3 months of age, slightly less time at 6 months and significantly less time at one year of age compared to wild-type, although performance improved after repeated training

• on an accelerating rotarod test, 3-4 week old mutants did not show a difference in performance compared to wild-type while at 4 months of age, mutants remained on the rod for a significantly shorter time, however performance was improved and reached the wild-type level after repeat testing

nervous system

thin cerebellar granule layer ( J:94369 )

• thickness of the internal granule layer was significantly reduced at P21, P28 and in adult mutants

• granule cell density was markedly reduced between P10 and P28 compared to wild-type and Grin2c null mice, indicating that reduction is due to Grin2b overexpression and not due to lack of Grin2c

abnormal cerebellar molecular layer ( J:94369 )

• the number of synapses between excitatory fibers and Purkinje cell dendritic spines in the molecular layer was reduced by about one third in adult mutants

thin cerebellar molecular layer ( J:94369 )

• the molecular layer was significantly reduced at P10 and this difference persisted until adulthood