Phenotypes Associated with This Genotype

Genotype
MGI:3513670

• Allelic Composition: Fgf2^tm2Doe/Fgf2^tm2Doe
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased bone mineral density of vertebrae ( J:147213 )

• vertebral BMD is reduced by 16% compared to wild-type controls

abnormal bone marrow morphology ( J:147213 )

• number and area of mineralized nodules are reduced in bone marrow stromal cells (BMSC)

decreased bone mineral content ( J:147213 )

• vertebral BMC is reduced by 30% compared to wild-type controls

cardiovascular system

decreased cardiac muscle contractility ( J:119652 )

• recovery of contractile function in DMSO-treated heart following ischemia-reperfusion injury is decreased as compared to wild-type (47 +/-5% vs 60 +/-7%)

• +dP/dt (derivative of change in contractile pressure over time) is decreased following ischemic-reperfusion injury in DMSO treated hearts

abnormal cardiac muscle relaxation ( J:119652 )

• -dP/dt (derivative of change in relaxation pressure over time) is increased as compared to wild-type following ischemic-reperfusion injury in DMSO treated hearts

decreased left ventricle systolic pressure ( J:119652 )

• LVSP is decreased as compared to wild-type following ischemic-reperfusion injury in DMSO treated hearts

cellular

increased cardiomyocyte apoptosis ( J:119652 )

• mice exhibit an increase TUNEL-positive cells (indicator of late stage apoptosis) in non-ischemic hearts as compared to wild-type

• following ischemia-reperfusion injury mice exhibit an increase TUNEL-positive cells (indicator of late stage apoptosis) in DMSO- treated hearts as compared to wild-type

muscle

decreased cardiac muscle contractility ( J:119652 )

• recovery of contractile function in DMSO-treated heart following ischemia-reperfusion injury is decreased as compared to wild-type (47 +/-5% vs 60 +/-7%)

• +dP/dt (derivative of change in contractile pressure over time) is decreased following ischemic-reperfusion injury in DMSO treated hearts

abnormal cardiac muscle relaxation ( J:119652 )

• -dP/dt (derivative of change in relaxation pressure over time) is increased as compared to wild-type following ischemic-reperfusion injury in DMSO treated hearts

increased cardiomyocyte apoptosis ( J:119652 )

• mice exhibit an increase TUNEL-positive cells (indicator of late stage apoptosis) in non-ischemic hearts as compared to wild-type

• following ischemia-reperfusion injury mice exhibit an increase TUNEL-positive cells (indicator of late stage apoptosis) in DMSO- treated hearts as compared to wild-type