Phenotypes Associated with This Genotype

Genotype
MGI:3513474

• Allelic Composition: Prl4a1^tm1Soar/Prl4a1^tm1Soar
• Genetic Background: CD-1.Cg-Prlpa^tm1Soar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

decreased embryo size ( J:94464 )

• profound growth retardation of embryos after 2 days of hypoxia exposure with embryo-placental structures undergoing resorption by E11.5

abnormal placenta morphology ( J:94464 )

abnormal trophoblast giant cell morphology ( J:94464 )

• trophoblast cell-vascular interactions were impaired and trophoblast cells associated with the ectoplacental cone did not grow into the mesometrial chamber in nulls exposed to hypoxia

abnormal ectoplacental cone morphology ( J:94464 )

• ectoplacental cone expansion into the mesometrial chamber at E8.5 and 9.5 did not occur after exposure to hypoxia

abnormal placenta development ( J:94464 )

• hemochorial placentation failed in nulls exposed (at E7.5-E12.5) to hypobaric hypoxia, leading to impaired nutrient delivery to extraembryonic and embryonic tissues

growth/size/body

decreased embryo size ( J:94464 )

• profound growth retardation of embryos after 2 days of hypoxia exposure with embryo-placental structures undergoing resorption by E11.5

reproductive system

female infertility ( J:94464 )

♀ • inability to maintain pregnancy after exposure to hypobaric hypoxia