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Phenotypes Associated with This Genotype
Genotype
MGI:3512883
Allelic
Composition
Wt1tm1Vih/Wt1+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wt1tm1Vih mutation (0 available); any Wt1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• several mice died at 4 to 5 months of age

homeostasis/metabolism
• 100% of males and 43% of females at 4 months of age and 71% of females at 10 to 12 months of age displayed proteinuria

renal/urinary system
• 100% of males and 43% of females at 4 months of age and 71% of females at 10 to 12 months of age displayed proteinuria
• effacement of podocyte foot processes
• 33% of males and 0% of females by 2 months of age and 100% of males and 43% of females at 4 months of age displayed glomerulosclerosis
• medullary regions of the kidneys had dilated tubules and protein casts, a few glomeruli with segmental sclerosis, and predominately glomeruli with global mesangial sclerosis
• glomeruli displayed severe thickening of the glomerular basement membrane

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Denys-Drash syndrome DOID:3764 OMIM:194080
J:94225


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory