About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3512741
Allelic
Composition
Lgr5tm1Ah/Lgr5tm1Ah
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1Ah mutation (0 available); any Lgr5 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died within 24 hours after birth with empty stomachs filled with air (J:94196)
• died within 24 hours after birth with empty stomachs filled with air (J:94196)

behavior/neurological
• stomachs were empty and filled with air presumably due to a suckling defect (J:94196)
• stomachs were empty and filled with air presumably due to a suckling defect (J:94196)

growth/size/body
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible (J:94196)
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible (J:94196)
• gradual distension of the abdomen after birth, so that by 12 hours after birth, the entire gastrointestinal tract became distended (J:94196)
• gradual distension of the abdomen after birth, so that by 12 hours after birth, the entire gastrointestinal tract became distended (J:94196)

homeostasis/metabolism
• mutants became gradually cyanotic with gasping respirations (J:94196)
• mutants became gradually cyanotic with gasping respirations (J:94196)

respiratory system
• pressure against the diaphragm from the distended abdomen resulted in respiratory failure (J:94196)
• pressure against the diaphragm from the distended abdomen resulted in respiratory failure (J:94196)

digestive/alimentary system
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible (J:94196)
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible (J:94196)

craniofacial
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible (J:94196)
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible (J:94196)

Mouse Models of Human Disease
OMIM ID Ref(s)
Ankyloglossia 106280 J:94196


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory