About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3512741
Allelic
Composition
Lgr5tm1Ah/Lgr5tm1Ah
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1Ah mutation (0 available); any Lgr5 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died within 24 hours after birth with empty stomachs filled with air

behavior/neurological
• stomachs were empty and filled with air presumably due to a suckling defect

growth/size/body
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible
• gradual distension of the abdomen after birth, so that by 12 hours after birth, the entire gastrointestinal tract became distended

homeostasis/metabolism
• mutants became gradually cyanotic with gasping respirations

respiratory system
• pressure against the diaphragm from the distended abdomen resulted in respiratory failure

digestive/alimentary system
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible

craniofacial
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible

Mouse Models of Human Disease
OMIM ID Ref(s)
Ankyloglossia 106280 J:94196


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory