Phenotypes Associated with This Genotype

Genotype
MGI:3512687

• Allelic Composition: Htra2^tm1Jdo/Htra2^tm1Jdo; Diablo^tm1Mak/Diablo^tm1Mak
• Genetic Background: involves: 129P/Ola * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal stationary movement ( J:94227 )

• progressive movement disorder beginning at P18, identical to the phenotype observed in homozygous Prss25 null mice

cellular

increased apoptosis ( J:94227 )

• increased sensitivity to apoptosis induction by DNA-damaging agent etoposide

growth/size/body

decreased body size ( J:94227 )

decreased body weight ( J:94227 )

• failed to gain weight after P18 and exhibited a phenotype identical to homozygous Prss25 null mice