Mouse Genome Informatics
cx
    Fgf23tm1Blan/Fgf23tm1Blan
PhexHyp/Y

Not Specified
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• higher serum phosphate levels than in hemizygous Phex mice with levels similar to Fgf23 homozygotes

limbs/digits/tail
• longer and thinner femurs compared to compound heterozygotes and hemizygous Phex, with relatively regular appearing growth plates

skeleton
• longer and thinner femurs compared to compound heterozygotes and hemizygous Phex, with relatively regular appearing growth plates
• overall bone mineralization resembled that of homozygous Fgf23 mutants, including nodular deformities in ribs and paws at 3 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Hypophosphatemic Rickets, Autosomal Dominant; ADHR 193100 J:94041