Phenotypes Associated with This Genotype

Genotype
MGI:3512422

• Allelic Composition: Myl2^tm1(cre)Krc/Myl2⁺; Txnrd2^tm1Marc/Txnrd2^tm1.1Marc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal myocardial fiber mitochondrial morphology ( J:94136 )

• swollen or destroyed mitochondrial cristae

mortality/aging

neonatal lethality, complete penetrance ( J:94136 )

• mutants die within several hours after birth

cardiovascular system

liver vascular congestion ( J:94136 )

• liver congestion

abnormal myocardial fiber morphology ( J:94136 )

• myocardial cells are severely distorted with pycnotic nuclei, cytoplasmic vacuolization, and reduced cross-striation

abnormal myocardial fiber mitochondrial morphology ( J:94136 )

• swollen or destroyed mitochondrial cristae

dilated heart atrium ( J:94136 )

globular heart ( J:94136 )

• globular heart shape

thin ventricular wall ( J:94136 )

congestive heart failure ( J:94136 )

• mutants show clinical features of congestive heart failure

homeostasis/metabolism

edema ( J:94136 )

liver/biliary system

liver vascular congestion ( J:94136 )

• liver congestion

muscle

abnormal myocardial fiber morphology ( J:94136 )

• myocardial cells are severely distorted with pycnotic nuclei, cytoplasmic vacuolization, and reduced cross-striation

abnormal myocardial fiber mitochondrial morphology ( J:94136 )

• swollen or destroyed mitochondrial cristae