Phenotypes Associated with This Genotype

Genotype
MGI:3512162

• Allelic Composition: Nrp1^tm1Hfu/Nrp1^tm1Hfu
• Genetic Background: involves: CD-1 * JF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

delayed neuronal migration ( J:94050 )

• delayed tangential somata migration of facial branchiomotor neurons that resulted in the separation of the migratory stream into several distinct streams on the ventricular side of the hindbrain

• facial branchiomotor neuron somata emerged on the pial side in an ectopic anterior location during radial migration

• migration defects are not due to abnormal hindbrain segmentation, vascular defects in the hindbrain or axon guidance defects in the periphery

abnormal facial motor nucleus morphology ( J:94050 )

• nuclei on the pial side were elongated or dumbbell-shaped and in severe cases, the entire nucleus was shifted anteriorly

abnormal facial nerve morphology ( J:94050 )

• defasciculated facial nerve

abnormal trigeminal nerve morphology ( J:94050 )

• defasciculated trigeminal nerve branches

cellular

delayed neuronal migration ( J:94050 )

• delayed tangential somata migration of facial branchiomotor neurons that resulted in the separation of the migratory stream into several distinct streams on the ventricular side of the hindbrain

• facial branchiomotor neuron somata emerged on the pial side in an ectopic anterior location during radial migration

• migration defects are not due to abnormal hindbrain segmentation, vascular defects in the hindbrain or axon guidance defects in the periphery