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Phenotypes Associated with This Genotype
Genotype
MGI:3511897
Allelic
Composition
Myo7aHdb/Myo7aHdb
Genetic
Background
C3HeB/FeJ-Myo7aHdb/Ieg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7aHdb mutation (1 available); any Myo7a mutation (116 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Stereocilia abnormalities in the Organ of Corti of Myo7aHdb/Myo7a+ and Myo7aHdb/Myo7aHdb mice at P20 and 3 months

behavior/neurological
• increased head bobbing observed following weaning compared to heterozygotes
• increased hyperactivity after weaning compared to heterozygotes

hearing/vestibular/ear
• by 3 months, very few inner hair cell stereocilia remained in the apex
• at P20, apical inner hair cell stereocilia fusion had progressed such that the phenotype resembled the 3-month heterozygote phenotype
• by 3 months, very few outer hair cell stereocilia remained in the apex
• 20-23 day old mutants exhibited increased compound action potential from the round window of the cochlea across all frequencies (3-30kHz)

nervous system
• by 3 months, very few inner hair cell stereocilia remained in the apex
• at P20, apical inner hair cell stereocilia fusion had progressed such that the phenotype resembled the 3-month heterozygote phenotype
• by 3 months, very few outer hair cell stereocilia remained in the apex
• 20-23 day old mutants exhibited increased compound action potential from the round window of the cochlea across all frequencies (3-30kHz)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory