Mouse Genome Informatics
hm
    Leprtm1.2Chua/Leprtm1.2Chua
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Obesity in Leprtm1.2Chua/Leprtm1.2Chua mice

behavior/neurological
• males hyperphagic, consume 34.8% more food in a given period

growth/size/body
• males are 58.6% heavier than normal and females are 140.1% heavier

homeostasis/metabolism
• males are cold intolerant
• males were severely hyperglycemic
• insulin concentration about 2.6X normal

reproductive system

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:94019