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Phenotypes Associated with This Genotype
Genotype
MGI:3511748
Allelic
Composition
Leprtm1.2Chua/Leprtm1.2Chua
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.2Chua mutation (0 available); any Lepr mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Obesity in Leprtm1.2Chua/Leprtm1.2Chua mice

behavior/neurological
• males hyperphagic, consume 34.8% more food in a given period

growth/size/body
• males are 58.6% heavier than normal and females are 140.1% heavier

homeostasis/metabolism
• males are cold intolerant
• males were severely hyperglycemic
• insulin concentration about 2.6X normal

reproductive system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
obesity DOID:9970 OMIM:601665
J:94019


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory