Phenotypes Associated with This Genotype

Genotype
MGI:3511456

• Allelic Composition: tmgc42/tmgc42
• Genetic Background: Mixed stock

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal migration ( J:92490 )

• ectopic neurons located in CA1 stratum oriens of the hippocampus

abnormal hippocampus CA1 region morphology ( J:92490 )

• abnormal number of ectopic NeuN-positive cells in Stratum Oriens CA1 region of the hippocampus

• neuronal cell type(s) that make up this ectopic population are undetermined

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:92490 )

• ABR thresholds of 175TNR are elevated significantly at 32 kHz (4.7 x SD), but insignificantly at click (0.6 x SD), 8 kHz (0.9 x SD) and 16 kHz (1.8 x SD)

impaired hearing ( J:92490 )

• high frequency hearing loss

cellular

abnormal neuronal migration ( J:92490 )

• ectopic neurons located in CA1 stratum oriens of the hippocampus