Mouse Genome Informatics
ht
    Zic1/Zic4tm1Kjmi/Zic1+
involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• severely affected heterozygotes (15% of all heterozygotes) do not survive past weaning

behavior/neurological
• severely affected heterozygotes (15% of all heterozygotes) do not develop a normal righting reflex by P10

growth/size
• average body weight in severely affected heterozygotes (15% of all heterozygotes) is 45% that of wild-type littermates

nervous system
• in 85% of heterozygotes mild defects are seen in the anterior folia
• in 15% of heterozygotes severe foliar defects are seen
• in mildly affected heterozygotes, the vermis is slightly smaller compared to wild-type mice
• in severely affected heterozygotes disproportionate vermis hypoplasia is seen

Mouse Models of Human Disease
OMIM IDRef(s)
Dandy-Walker Syndrome; DWS 220200 J:93955