Phenotypes Associated with This Genotype

Genotype
MGI:3511178

• Allelic Composition: Myb^tm1Epr/Myb^tm1Epr; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:93481 )

• cellularity of the thymus is reduced to 11% of controls

abnormal T cell differentiation ( J:93481 )

abnormal double-negative T cell morphology ( J:93481 )

• thymocytes accumulate at the DN3 stage

• reduced numbers of cells at the DN4 stage

decreased double-positive T cell number ( J:93481 )

• double positive cell population reduced to 62% of normal

immune system

thymus hypoplasia ( J:93481 )

• cellularity of the thymus is reduced to 11% of controls

abnormal T cell differentiation ( J:93481 )

abnormal double-negative T cell morphology ( J:93481 )

• thymocytes accumulate at the DN3 stage

• reduced numbers of cells at the DN4 stage

decreased double-positive T cell number ( J:93481 )

• double positive cell population reduced to 62% of normal

endocrine/exocrine glands

thymus hypoplasia ( J:93481 )

• cellularity of the thymus is reduced to 11% of controls