Phenotypes Associated with This Genotype

Genotype
MGI:3511165

• Allelic Composition: Traf3ip2^tm1.1Lix/Traf3ip2^tm1.1Lix
• Genetic Background: involves: 129/Sv * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:93923 )

increased dendritic cell number ( J:93923 )

• the number of dendritic cells is increased in the spleen

increased B cell number ( J:93923 )

• the total splenic B cell population is increased however the proportions of different B cell stages are the same as in wild-type littermates

abnormal spleen B cell corona morphology ( J:93923 )

• the density of B cell zones is increased

increased immunoglobulin level ( J:93923 )

increased IgE level ( J:93923 )

increased IgG level ( J:93923 )

• IgG subclasses except for IgG3 are increased

• both T cell dependent and independent antigens elicit increased antigen-specific responses

immune system

abnormal immune system morphology ( J:93923 )

enlarged spleen ( J:93923 )

increased dendritic cell number ( J:93923 )

• the number of dendritic cells is increased in the spleen

increased B cell number ( J:93923 )

• the total splenic B cell population is increased however the proportions of different B cell stages are the same as in wild-type littermates

abnormal spleen B cell corona morphology ( J:93923 )

• the density of B cell zones is increased

enlarged lymph nodes ( J:93923 )

• at 3 weeks of age the lymph nodes are enlarged from lymphoid hyperplasia, increased germinal centers, and accumulation of plasma cells

lymphoid hyperplasia ( J:93923 )

abnormal immune system physiology ( J:93923 )

increased immunoglobulin level ( J:93923 )

increased IgE level ( J:93923 )

increased IgG level ( J:93923 )

• IgG subclasses except for IgG3 are increased

• both T cell dependent and independent antigens elicit increased antigen-specific responses

increased autoantibody level ( J:93923 )

increased anti-double stranded DNA antibody level ( J:93923 )

• anti-dsDNA IgG antibodies are detected

increased anti-histone antibody level ( J:93923 )

• anti-histone IgG antibodies are detected

increased anti-single stranded DNA antibody level ( J:93923 )

• anti-ssDNA IgG antibodies are detected

increased inflammatory response ( J:93923 )

• inflammation is seen in multiple tissues including the skin

respiratory system inflammation ( J:93923 )

• upper respiratory airway inflammation is seen

respiratory system

respiratory system inflammation ( J:93923 )

• upper respiratory airway inflammation is seen

growth/size/body

enlarged spleen ( J:93923 )