Phenotypes Associated with This Genotype

Genotype
MGI:3511011

• Allelic Composition: Irs2^tm1Mfw/Irs2^tm1Mfw; Tg(Ins2-Irs2)13Mfw/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:94000 )

N • mice survived more than a year after single Irs2 homozygous mice died

vision/eye

abnormal b-wave implicit time ( J:98107 )

• rod-driven b-wave implicit time is delayed

decreased a-wave amplitude ( J:98107 )

• the amplitude of the a-wave is reduced at all flash intensities tested

decreased b-wave amplitude ( J:98107 )

• rod-driven b-wave amplitudes are reduced

abnormal cone electrophysiology ( J:98107 )

• light-adapted responses are reduced

• across stimulus conditions, cone ERGs are reduced on average to 64.9 % of control response, however the implicit time is not changed

abnormal rod electrophysiology ( J:98107 )

• dark-adapted ERGs are reduced

• across stimulus conditions, rod ERG responses are reduced on average to 34.9% of controls

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:94000 )

• increased proliferation and number of normal-sized beta cells compared to wild-type and single Irs2 homozygous mice

homeostasis/metabolism

increased circulating insulin level ( J:94000 )

• expression of Irs2 in beta cells resulted in a persistent compensatory hyperinsulinemia preventing the development of diabetes

• during intraperitoneal glucose challenge, no glucose intolerance was seen unlike in single Irs2 homozygous mice