Phenotypes Associated with This Genotype

Genotype
MGI:3511007

• Allelic Composition: Tg(Ins2-Irs2)13Mfw/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:94000 )

• at 8 weeks, islet area increased twofold mainly due to increased density of normal-sized islets

• following streptozotocin treatment, beta cell apoptosis was reduced by greatear than 50% compared to wild-type and transgenics did not develop diabetes

increased insulin secretion ( J:94000 )

• 2.7-fold increase in pancreatic insulin content, 3-fold increase in insulin secretion during the first 30 min of an intraperitoneal glucose challenge, however glucose homeostasis was normal during the 24 week experiment and mice never developed diabetes

homeostasis/metabolism

increased insulin secretion ( J:94000 )

• 2.7-fold increase in pancreatic insulin content, 3-fold increase in insulin secretion during the first 30 min of an intraperitoneal glucose challenge, however glucose homeostasis was normal during the 24 week experiment and mice never developed diabetes

increased circulating insulin level ( J:94000 )

• transgenic mice fed a high-fat diet became obese and exhibited an increase in insulin levels but had normal fasting glucose levels and normal glucose tolerance at a young age

improved glucose tolerance ( J:94000 )

• improved glucose tolerance compared to wild-type on a high fat diet and in older mice