Phenotypes Associated with This Genotype

Genotype
MGI:3510961

• Allelic Composition: Ap3m2^tm1Ohno/Ap3m2^tm1Ohno
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

seizures ( J:93312 )

increased susceptibility to pharmacologically induced seizures ( J:93312 )

• increased susceptibility to pentylenetetrazole (PTZ)

abnormal kindling response ( J:93312 )

• class 5 seizures induced after only two stimulations as opposed to 10-12 stimulations in controls

nonconvulsive seizures ( J:93312 )

• occasional adults with spontaneous epileptic seizures

• by 15 weeks of age more than half of mice experienced seizures

nervous system

seizures ( J:93312 )

increased susceptibility to pharmacologically induced seizures ( J:93312 )

• increased susceptibility to pentylenetetrazole (PTZ)

abnormal kindling response ( J:93312 )

• class 5 seizures induced after only two stimulations as opposed to 10-12 stimulations in controls

nonconvulsive seizures ( J:93312 )

• occasional adults with spontaneous epileptic seizures

• by 15 weeks of age more than half of mice experienced seizures

abnormal synaptic vesicle morphology ( J:93312 )

• diameter of synaptic vesicles in inhibitory terminals is smaller

abnormal hippocampus morphology ( J:93312 )

• fewer synaptic vesicles/unit area than in controls

abnormal nervous system electrophysiology ( J:93312 )

• electrocorticogram revealed all mice with an abnormal epileptic pattern

enhanced long-term potentiation ( J:93312 )

• increased long term potentiation in hippocampal CA1 using weak conditioning stimuli

decreased neurotransmitter release ( J:93312 )

• potassium evoked GABA release is impaired after 8 weeks of age

• amounts of vesicular GABA transporter significantly reduced in synaptosomal lysates

• impaired GABAergic inhibition in temporoammonic pathway between entorhinal cortex and CA1 pyramidal cells

cellular

abnormal synaptic vesicle morphology ( J:93312 )

• diameter of synaptic vesicles in inhibitory terminals is smaller