Phenotypes Associated with This Genotype

Genotype
MGI:3510873

• Allelic Composition: Met^tm2Kln/Met^tm2Kln
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:94030 )

• born alive but died immediately after birth of respiratory failure

embryo

embryo phenotype ( J:94030 )

N • placental development occurred when CD1 made up part of the genetic background

growth/size/body

abnormal fetal growth/weight/body size ( J:94030 )

• mildly reduced body weight

liver/biliary system

dilated liver sinusoidal space ( J:94030 )

abnormal liver development ( J:94030 )

• liver structure loose with dissociated parenchymal cells

decreased liver weight ( J:94030 )

• liver weight reduced about 60%

muscle

abnormal myoblast migration ( J:94030 )

• myoblasts fail to migrate into limbs

abnormal myogenesis ( J:94030 )

• 55% reduction in fetal myoblasts

abnormal diaphragm morphology ( J:94030 )

• severely reduced diapragm

decreased skeletal muscle mass ( J:94030 )

• severely reduced muscle mass in limbs, transverse sections of muscles reduced about 40%

• diaphragm muscle severely reduced

respiratory system

respiratory failure ( J:94030 )

• occurs immediately after birth

nervous system

abnormal motor neuron innervation pattern ( J:94030 )

• motor axon outgrowth generally abnormal

abnormal somatic motor system morphology ( J:94030 )

• branches of the nervus thoracodorsalis were completely absent

cardiovascular system

dilated liver sinusoidal space ( J:94030 )

cellular

abnormal myoblast migration ( J:94030 )

• myoblasts fail to migrate into limbs