Phenotypes Associated with This Genotype

Genotype
MGI:3510872

• Allelic Composition: Met^tm1Kln/Met^tm1Kln
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:94030 )

• between E13.5 and E15.5

embryo

small placenta ( J:94030 )

• small placentas

growth/size/body

abnormal fetal growth/weight/body size ( J:94030 )

• mildly reduced body weight

liver/biliary system

dilated liver sinusoidal space ( J:94030 )

abnormal liver development ( J:94030 )

• liver structure loose with dissociated parenchymal cells

• increased levels of apoptosis at E12.5

decreased liver weight ( J:94030 )

• liver weight reduced about 60%

muscle

abnormal myoblast migration ( J:94030 )

• myoblasts fail to migrate into limbs

abnormal myogenesis ( J:94030 )

• 55% reduction in fetal myoblasts

decreased skeletal muscle mass ( J:94030 )

• severely reduced muscle mass in limbs, transverse sections of muscles reduced about 40%

• diaphragm muscle also reduced

nervous system

abnormal somatic motor system morphology ( J:94030 )

• normal outgrowth of motor axons in the hindlimbs

• anterior nerves were defective in development

cardiovascular system

dilated liver sinusoidal space ( J:94030 )

cellular

abnormal myoblast migration ( J:94030 )

• myoblasts fail to migrate into limbs