Phenotypes Associated with This Genotype

Genotype
MGI:3510865

• Allelic Composition: Cebpb^tm1Pfj/Cebpb^tm1Pfj
• Genetic Background: B6.Cg-Cebpb^tm1Pfj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of induced tumors ( J:73558 )

• homozygotes are completely refractory to skin tumorigenesis induced by a variety of carcinogens, tumor promoters, and carcinogenesis protocols that, in wild-type mice, cause tumors that contain mutant oncogenic Ha-ras or Ki-ras

decreased incidence of tumors by chemical induction ( J:73558 )

• homozygotes are completely resistant to DMBA/TPA-induced papillomas

• also, homozygotes are completely resistant to MNNG/TPA-induced papillomas (involving oncogenic mutations in the 12th codon of either Ha-ras or Ki-ras), and completely resistant to skin tumors in a DMBA/mirex initiation/promotion protocol

integument

increased keratinocyte apoptosis ( J:73558 )

• compared with wild-type, homozygotes show a 17-fold increase in the number of basal apoptotic keratinocytes in response to DMBA treatment

• in contrast, mutant and wild-type mice show a similar increase in the number of apoptotic epidermal keratinocytes in response to ultraviolet-B irradiation

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:73558 )

• homozygotes are completely resistant to DMBA/TPA-induced papillomas

• also, homozygotes are completely resistant to MNNG/TPA-induced papillomas (involving oncogenic mutations in the 12th codon of either Ha-ras or Ki-ras), and completely resistant to skin tumors in a DMBA/mirex initiation/promotion protocol

cellular

increased keratinocyte apoptosis ( J:73558 )

• compared with wild-type, homozygotes show a 17-fold increase in the number of basal apoptotic keratinocytes in response to DMBA treatment

• in contrast, mutant and wild-type mice show a similar increase in the number of apoptotic epidermal keratinocytes in response to ultraviolet-B irradiation