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Phenotypes Associated with This Genotype
Genotype
MGI:3510675
Allelic
Composition		 Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-Irs2)13Mfw/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs2tm2Mfw mutation (0 available); any Irs2 mutation (37 available)
Tg(Ins2-cre)25Mgn mutation (3 available)
Tg(Ins2-Irs2)13Mfw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:93415 )
• compound mutants continue to gain excess weight

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:93415 )
N
• compound mutants do not develop hyperglycemia

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory