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Phenotypes Associated with This Genotype
Genotype
MGI:3510652
Allelic
Composition
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
Genetic
Background
either: 129/Sv or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Lpr mutation (0 available); any Psen1 mutation (28 available)
Tg(Thy1-APPSL)28Lpr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• accelerated rate of A-beta deposition starting at 2.5 months of age
• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas
• astrocytic and microglial activation around amyloid plaques
• marked reduction in thickness of the hippocampal pyramidal cell layer by 10 months of age
• no amyloid plaques in the CA1/2 pyramidal cell layer

homeostasis/metabolism
• accelerated rate of A-beta deposition starting at 2.5 months of age
• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas
• astrocytic and microglial activation around amyloid plaques

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:93770
Alzheimer Disease; AD 104300 J:93770


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory