Mouse Genome Informatics
cx
    Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0

either: 129/Sv or (involves: 129/Sv * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• accelerated rate of A-beta deposition starting at 2.5 months of age
• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas
• astrocytic and microglial activation around amyloid plaques
• marked reduction in thickness of the hippocampal pyramidal cell layer by 10 months of age
• no amyloid plaques in the CA1/2 pyramidal cell layer

homeostasis/metabolism
• accelerated rate of A-beta deposition starting at 2.5 months of age
• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas
• astrocytic and microglial activation around amyloid plaques

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease 3 607822 J:93770
Alzheimer Disease; AD 104300 J:93770