Phenotypes Associated with This Genotype

Genotype
MGI:3510547

• Allelic Composition: Raf1^tm2Bacc/Raf1^tm2Bacc; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

thin myocardium ( J:93418 )

• posterior wall thickness is significantly decreased

enlarged heart ( J:93418 )

• the heart is enlarged; however, heart weight is not increased

dilated heart left ventricle ( J:93418 )

cardiac fibrosis ( J:93418 )

decreased cardiac muscle contractility ( J:93418 )

• fractional shortening indicate that cardiac contractility is significantly decreased

decreased heart left ventricle muscle contractility ( J:93418 )

• reduced maximal and minimal first derivatives of left ventricular pressure indicate that cardiac contractility and relaxation are significantly decreased

muscle

thin myocardium ( J:93418 )

• posterior wall thickness is significantly decreased

decreased cardiac muscle contractility ( J:93418 )

• fractional shortening indicate that cardiac contractility is significantly decreased

decreased heart left ventricle muscle contractility ( J:93418 )

• reduced maximal and minimal first derivatives of left ventricular pressure indicate that cardiac contractility and relaxation are significantly decreased

increased cardiomyocyte apoptosis ( J:93418 )

• increased apoptosis in the heart is seen from 3-5 weeks of age but not at 2 weeks or after 6 weeks of age

cellular

increased cardiomyocyte apoptosis ( J:93418 )

• increased apoptosis in the heart is seen from 3-5 weeks of age but not at 2 weeks or after 6 weeks of age

growth/size/body

enlarged heart ( J:93418 )

• the heart is enlarged; however, heart weight is not increased