Phenotypes Associated with This Genotype

Genotype
MGI:3510463

• Allelic Composition: Ntrk1^tm1Tes/Ntrk1^tm1Tes; Tg(Tuba1-cre)1Tes/0
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased B-1 B cell number ( J:93578 )

• B1 cell numbers in the peritoneal cavity are increased by 30% in mice older than 12 months but not in younger animals

• no other immune cell morphological abnormalities were observed

abnormal mast cell physiology ( J:93578 )

• bone marrow mast cells release modestly but significantly reduced levels of beta-hexoseaminidase when stimulated

increased immunoglobulin level ( J:93578 )

increased IgG1 level ( J:93578 )

• increased serum levels of IgG1 and IgG2a

increased IgG2a level ( J:93578 )

increased IgM level ( J:93578 )

immune system

increased B-1 B cell number ( J:93578 )

• B1 cell numbers in the peritoneal cavity are increased by 30% in mice older than 12 months but not in younger animals

• no other immune cell morphological abnormalities were observed

abnormal mast cell physiology ( J:93578 )

• bone marrow mast cells release modestly but significantly reduced levels of beta-hexoseaminidase when stimulated

increased immunoglobulin level ( J:93578 )

increased IgG1 level ( J:93578 )

• increased serum levels of IgG1 and IgG2a

increased IgG2a level ( J:93578 )

increased IgM level ( J:93578 )